Ebby Health - Why glucose is the key to migraine relief

Why Glucose is the Key to Migraine Relief

Blood sugar fluctuations after eating or drinking can trigger inflammatory processes, which in turn may lead to migraine attacks. To better understand this connection, let’s take a closer look at the science behind Ebby.

RESEARCH BACKGROUND

The Metabolic Face of Migraine

Discover the historical development of migraine research that has shaped the foundation of our studies and product development.

1930s

Concept of hypoglycemic headache due to "insulin shock"

Gray & Burtness, 1935

1950s

"Neurogenic hypoglycemia" and Seale Harris diet

Gyland, 1953

1970s

Glucose tolerance is impaired in migraine attacks

Shaw et al., 1977

1980s

Diet as migraine triggers

Diamond et al., 1986

1990s

Role of insulin resistance in migraine

Bic et al., 1996

2000s

Neurogenic inflammation: GPRP as link

Kristiansen & Edvinsson, 2010

2010s

Metabolic face of migraine

Evcili et al., 2018

2020s

Personalization of low-glycemic diet interventions

Gross et al., 2019

CLINICAL EVIDENCE

Evidence and Efficacy of Ebby

Learn more about our research and publications. For reference, in Europe and in all studies conducted to date, Ebby has been operating under the brand name “sinCephalea.”

Retrospective Study on Migraine Reduction Through a Personalized Low-Glycemic Diet

2022 Feb 20

"A Digital Health Application Allowing a Personalized Low-Glycemic Nutrition for the Prophylaxis of Migraine: Proof-of-Concept Data from a Retrospective Cohort Study"

Schröder T, Kühn G, Kordowski A, et al.

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Two Prospective Studies on Migraine Reduction Through the Use of sinCephalea

2022 Jul 17

"A Digital Therapeutic Allowing a Personalized Low-Glycemic Nutrition for the Prophylaxis of Migraine: Real World Data from Two Prospective Studies"

Lelleck VV, Schulz F, Witt O, et al.

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Study Protocol (RCT) for Demonstrating the Efficacy of sinCephalea

2022 Dec 12

"Efficacy of the Digital Therapeutic sinCephalea in the prophylaxis of migraine in patients with episodic migraine: study protocol for a digital, randomized, open-label, standard treatment controlled trial"

Schröder T, Brudermann HCB, Kühn G, et al.

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OUTCOMES

Results from our Proof of Concept Study

After a 16 week usage of Ebby, 62 patients with episodic migraines experienced the following results.

44%

Reduction in
Monthly Migraine Days

>47%

50% Responder Rate

>2.4

Days less Migraine
per Month

44%

Reduction in
Monthly Migraine Days

>47%

50% Responder Rate

>2.4

Days less Migraine
per Month

The Top 3 Blood Sugar-Related Factors influencing Migraines

1. Hypoglycemia

The neuropeptide CGRP reduces glucose transport into cells, inhibiting glycogen breakdown in muscles and the brain’s energy supply. A low blood sugar level stimulates this neuropeptide, promoting migraines.

Read the Study

2. Blood Sugar Spikes

Significant fluctuations in blood sugar levels after meals are closely linked to inflammatory processes that can trigger migraines.

Read the Study

3. Irregular Energy Supply

A short-term increase in blood sugar leads to reactive hypoglycemia, resulting in a glucose or energy deficit in the brain. A migraine attack acts as a protective mechanism, forcing the body into an energy-saving mode.

Read the Study

1. Hypoglycemia

The neuropeptide CGRP not only reduces glucose transport into cells but also inhibits glycogen breakdown in muscles, ultimately affecting the brain’s energy supply. As a result, a low blood sugar level triggers the release of this neuropeptide, which in turn promotes migraines.

Read the Study

2. Blood Sugar Spikes

Significant fluctuations in blood sugar levels after meals are directly linked to inflammatory processes, which in turn can trigger migraines.

Read the Study

3. Irregular Energy Supply

A short-term increase in blood sugar can quickly lead to reactive hypoglycemia, ultimately resulting in a glucose or energy deficit in the brain. As a response, a migraine attack acts as a protective mechanism, forcing the body into an energy-saving mode.

Read the Study

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TAKE THE FIRST STEP

Start your Path to Migraine Relief Today

Join thousands of users who have found real relief with personalized nutrition and smart tracking. Your journey to fewer migraines starts here.